Sjögren's syndrome muscle wasting

Muscle ultrastructure in a case of mixed connective tissue disease and Sjögren's syndrome. Finol HJ, Márquez A, Torres SH. A 29-year-old black woman with clinical and serological diagnoses of Sjörgren's Syndrome (SS) and mixed connective tissue disease (MCTD) presented a very important muscular compromise with proximal, bilateral weakness. Severe muscle weakness in all four limbs may be a symptom of Sjögren's syndrome, a case report contends. Researchers hope their study will increase awareness about the multitude of ways Sjögren's syndrome may be recognized, and subsequently improving the diagnosis Sjögren's syndrome is an example of an autoimmune syndrome. In autoimmune disorders, the immune system, which normally protects the body from infection and cancers, may cause injury to the body's own tissues Objective: Although muscle pain is common in primary Sjögren's syndrome (SS), the underlying mechanisms are mainly unknown. We studied all patients with SS at our rheumatology unit with respect to muscle pain in general and to fibromyalgia (FM), and correlated clinical data to muscle biopsy findings

A place for people to discuss Sjögren's syndrome, a disorder where the body's immune system attacks its own healthy cells that produce saliva and tears. The two most common symptoms are dry eyes and a dry mouth. Share news, articles, personal experience, support, encouragement, and discuss all things Sjogren. 2.6k Sjögren's syndrome is a chronic disorder that causes insufficient moisture production in certain glands of the body, including the saliva-producing and tear-producing glands. The lungs, bowel and other organs are less often affected by Sjögren's syndrome. Appointments 216.444.260 Patients with Sjögren's can also have muscle weakness, paralysis, or complete loss of motor function, and they can have numbness on one side of the body (which is a hemisensory dysfunction) or numbness all over. Thes Primary Sjogren's syndrome patients commonly develop ataxia, which is a lack of voluntary coordination of muscle movements that includes gait abnormalities. But this is usually not associated with cerebellar atrophy, which takes place in the area of the brain responsible for muscle coordination and balance

Muscle ultrastructure in a case of mixed connective tissue

Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus Primary Sjögren's syndrome is a systemic autoimmune disease characterized by xerophthalmia and xerostomia, and is associated with systemic visceral involvement, including pneumonitis, renal tubular acidosis, pancreatitis, myositis, and occasionally lymphocytic proliferation Muscle involvement in primary Sjögren's syndrome (pSS) has a diverse clinical and pathological spectrum. One‐third of patients complain of myalgias and muscular weakness, symptoms that are often disturbing and disabling. Inflammatory muscle disease in the form of myositis is found in 3% of these patients [ 1 ] The Takeaway. Muscle wasting related to muscle atrophy, also known as sarcopenia, is often an overlooked condition, and most people don't think of the thyroid being at the root of it — but it is a common symptom of those with Hashimoto's. Sometimes it's related to thyroid levels — other times, to protein deficiency

Multiple Limb Weakness May Be Sign of Sjögren's, Case

Sjögren's syndrome can also cause swollen or painful joints, muscle pain or weakness, dry skin, rashes, brain fog (poor concentration or memory), numbness and tingling sensations in the arms and legs due to nerve involvement, heartburn, kidney problems and swollen lymph nodes Marinesco-Sjögren syndrome (OMIM 248800) is an autosomal recessive disorder characterized by intellectual disability, cerebellar ataxia with cerebellar atrophy, congenital cataracts, short stature, and delayed sexual development due to hypergonadotrophic hypogonadism. Most patients have elevated serum creatine kinase levels and myopathic. Sporadic bulbospinal muscle atrophy with facial-onset sensory neuropathy. Tangier disease, sarcoidosis, chronic basilar meningitis, or Sjögren's syndrome. Clinical and neurophysiological features of this patient resemble those of four recently reported patients who were affected with facial-onset sensorimotor neuropathy (FOSMN), a probably. What Is Muscle Wasting? M uscle wasting, or atrophy, is a muscle disorder resulting from the loss of muscle tissue which is characterized by thin muscles that have reduced strength and endurance. What Is Muscle Wasting In Celiac Disease and/or Gluten Sensitivity? Sjögren's Syndrome.

Neurologic Complications : Johns Hopkins Sjögren's Cente

Sjögren syndrome is a relatively common chronic, autoimmune, systemic, inflammatory disorder of unknown cause. It is characterized by dryness of the mouth, eyes, and other mucous membranes due to lymphocytic infiltration of exocrine glands and secondary gland dysfunction. Sjögren syndrome can affect various exocrine glands or other organs Muscle Atrophy can have different causes. It may be due to: Physical immobilization, i.e., prolonged immobilization of a muscle or muscle group. Hereditary myopathy, a hereditary disease that affects the muscles. Acquired myopathy, a disease of the muscles whose cause is not hereditary. A deterioration of the nervous system

Subclinical myositis is common in primary Sjögren's

Sjögren's syndrome (SjS, SS) is a long-term autoimmune disease that affects the body's moisture-producing (lacrimal and salivary) glands, and often seriously affects other organs systems, such as the lungs, kidneys, and nervous system. Primary symptoms are dryness (dry mouth and dry eyes), pain and fatigue 1. J Neurol Sci. 1989 Jan;89(1):103-13. Muscle pathology in Marinesco-Sjögren syndrome. Komiyama A(1), Nonaka I, Hirayama K. Author information: (1)Department of Neurology, Chiba University School of Medicine, Japan. Three of 4 adult patients with Marinesco-Sjögren syndrome (MSS; 2 males and 2 females, aged 26-31 years) in 2 families became non-ambulant because of slowly progressive muscular. A 29-year-old black woman with clinical and serological diagnoses of Sjörgren's Syndrome (SS) and mixed connective tissue disease (MCTD) presented a very important muscular compromise with proximal, bilateral weakness and wasting, an abnormal electromyogram, and elevated muscle enzymes

Muscle wasting in face? : Sjogren

Topical application of various agents have been used to treat the ichthyosis. Some clinical studies have found that a drug called zileuton can be beneficial in the treatment of SLS. In these studies, the drug successfully reduced the severity of the pruritis (itching), and improved the behavior of the treated child degeneration, necrosis, atrophy, and decreas- teria for Sjögren's syndrome: a revised version of the European criteria proposed by muscle, and smooth muscle. Several ran Muscle wasting is related to a poor quality of life and increased morbidity/ mortality. Two common but distinct conditions characterized by a loss of skeletal muscle mass are sarcopenia and cachexia. Sarcopenia, cachexia, and anorexic disorders (protein-energy malnutrition) represent the major causes of muscle-wasting disorders. It has been. Inclusion body myositis (IBM) is an inflammatory muscle disease characterized by progressive muscle weakness and wasting. Patients suffering from IBM usually develop symptoms of IBM after age 50; however, some patients may present with symptoms as early as their 30's

Sjögren's Syndrome: Causes, Symptoms, Diagnosis & Treatment

  1. Symptoms of nerve damage and muscle wasting include uncontrolled twitching, muscle cramping, decreased strength and changes in your skin, hair and nails, according to the National Institute of Neurological Disorders and Stroke. Advertisement. Neurological diseases that can cause muscle wasting include myasthenia gravis, Guillain-Barré syndrome.
  2. Muscle atrophy diet. Eat plenty of protein: Eating a diet rich in protein is key for improving muscle quality, developing new muscle fibers, and maintaining muscle mass overall. It is recommended.
  3. The official definition of wasting syndrome or cachexia is unintentional weight loss. Wasting syndrome can be life-threatening because it can't be reversed by nutritional means. The lost in weight is primarily due to muscle atrophy of the skeletal muscles. The atrophy is caused by increased rate of muscle catabolism or muscle breakdown
  4. Diseases That Causes Muscle Wasting. Polymyositis. Guillain-Barre Syndrome. Osteoarthritis. Written by Lindsay Boyers. 18 December, 2018. Muscle wasting, also called muscle atrophy, is the weakening or loss of muscle tissue 1. Muscle wasting causes a significant decrease in muscle strength and the ability to move the muscle, according to.
  5. There are 9 types of muscular dystrophy, with each type involving an eventual loss of strength, increasing disability, and possible deformity. The most well known of the muscular dystrophies is Duchenne muscular dystrophy (DMD), followed by Becker muscular dystrophy (BMD). Listed below are the 9 different types of muscular dystrophy
  6. Muscle wasting. WebMD Symptom Checker helps you find the most common symptom combinations and medical conditions related to muscle wasting. Click on the combination that matches your symptoms to find the conditions that may cause these problems. Or click on See All Conditions to see every condition related to muscle wasting. See All Condition

Neurologic Aspects of Sjögren's Syndrome by Dr

  1. Sjögren syndrome is one of the three most common systemic autoimmune diseases.1 As many as 1 to 2 million persons in the United states are affected ; the reported prevalence is between 0.05 and 4.
  2. Muscle wasting is a debilitating condition that develops with ageing and more rapidly with inactivity (bed rest) and in various systemic diseases (for example, cancer, renal failure, chronic.
  3. Marinesco-Sjögren syndrome with reduced cytochrome c oxidase in muscle. Kodama S(1), Komatsu M, Miyoshi M, Nakao H, Sakurai T, U M. Author information: (1)Department of Pediatrics, Himeji Red Cross Hospital, Japan. The present study deals with the sisters of Marinesco-sjögren syndrome without parental consanguinity
  4. Most variants of PSSM2 (P2, P3, P4 & P8) are Myofibrillar Myopathy which is a degenerative hereditary muscle disease that causes muscle wasting and weakness. With PSSM2 when damaged muscle tissue is torn down, there is an impaired ability to rebuild it, this makes PSSM2 horses more susceptible to muscle wasting especially as the horse already.
  5. Sarcopenia is the gradual loss of muscle mass that can affect people in their 30s and beyond. WebMD explains its symptoms, causes, diagnosis, and treatments

Cachexia / Wasting Syndrome. Cachexia is a condition which denotes the excessive loss of weight. It occurs because of the depletion of adipose tissue and muscle mass in people who are not trying. BACKGROUND AND PURPOSE: Cerebellar atrophy is considered the most prominent neuroradiologic finding in Marinesco-Sjögren syndrome (MSS). Our purpose was to investigate this neuroradiologic feature in a series of patients with MSS. METHODS: Five patients with MSS (age range, 5-19 years) underwent native MR imaging of the brain. The findings were assessed with particular attention to the. Muscle atrophy can have an adverse impact on your mobility. Several underlying health conditions or diseases can decrease muscle mass. As a result, you can experience wasting of muscles. One of the major reasons for the muscles wasting is the lack of physical movement or activity. It mainly affects people who are bedridden due to an injury or. Parsonage-Turner syndrome (PTS) is an uncommon neurological disorder characterized by rapid onset of severe pain in the shoulder and arm. This acute phase may last for a few hours to a few weeks and is followed by wasting and weakness of the muscles (amyotrophy) in the affected areas. PTS involves mainly the brachial plexus, the networks of.

In Sjogren's Syndrome, Cerebellar Atrophy Seen as a Rare

  1. Sjögren syndrome is a systemic chronic inflammatory disorder characterized by lymphocytic infiltrates in exocrine organs. Most individuals with Sjögren syndrome present with sicca symptoms, such as xerophthalmia (dry eyes), xerostomia (dry mouth), and parotid gland enlargement, which is seen in the image below
  2. Sjögren syndrome is the second most common autoimmune disorder after rheumatoid arthritis. There is a recognized female predilection with F:M ratio of ≈9:1. Patients typically present around the 4 th to 5 th decades
  3. Muscles are also checked for twitches and involuntary movements, which may indicate a nerve disease rather than a muscle disease. Doctors look for wasting away of muscle (atrophy), which can result from damage to the muscle or its nerves or from lack of use (disuse atrophy), as sometimes occurs with prolonged bed rest

This Potentially Fatal Syndrome Makes Your Body Literally

When I started researching this, I guessed that muscle wasting would only be a concern for those diagnosed with severe COPD when exertion became extremely difficult. However, estimates made in the early 2000's speculated that up to 50% of people with either mild or severe disease also suffered from some degree of skeletal muscle wasting Charcot-Marie-Tooth disease (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body. This disease is the most commonly inherited neurological disorder affecting about one in 2,500 people.. Currently, there are no curative treatments for this disorder, with. Sjögren syndrome is an autoimmune disorder. This means that the body's own immune system attacks its own cells and tissues by mistake. In this case, it attacks the glands that produce moisture. It commonly causes dry skin, dry eyes, and dry mouth

SJÖGREN'S SYNDROME OVERVIEW. Sjögren's syndrome is a chronic autoimmune disease in which the body's immune system inappropriately attacks self-tissues, particularly the glands that produce moisture in the eyes, the mouth, and elsewhere in the body; this causes the most common symptoms of Sjögren's syndrome, which are dry eyes and dry mouth Immunosuppressive therapy with steroids or other drugs are effective in reversing the disease in most patients, Mammen says. In his initial research, Mammen and his colleagues focused on 26 patients at the Johns Hopkins Myositis Center with necrotizing myopathy, a muscle-wasting disorder with no known cause. Sixteen were found to have a. This is the first autopsy case report of a syndrome with autosomal recessive inheritance, muscular atrophy, contracture, skin eruption, hyper γ-globulinemia, decreased subcutaneous fat, mental retardation and abnormal ECG findings. Skeletal muscles showed severe, discrete, multifocal muscular fibrosis which replaced several primary fasciculi. The tongue, heart and extraocular muscles showed. Sjögren's syndrome is an autoimmune disease most common in older women, though it can affect people of all ages. Autoimmune disorders cause your immune system to attack healthy parts of your.

Peripheral neuropathy, in the broadest sense, refers to a range of clinical syndromes affecting a variety of peripheral nerve cells and fibers, including motor, sensory, and autonomic fibers ( Box 1 ). Most peripheral neuropathies affect all fiber types to some extent. However, a single fiber type may be predominantly or exclusively affected in. Sjögren's (SHOW-grins) syndrome is an autoimmune disorder that reduces the amount of tears in the eyes and saliva in the mouth. As a result, people with Sjögren's syndrome have dry mouth and dry eyes. Dry mouth affects taste, makes chewing and swallowing more difficult, and increases the risk for cavities, tooth loss, and infections in the mouth

What conditions can cause muscle wasting

Cerebellar ataxia represents a rare and severe complication of Sjӧgren syndrome (SS), especially with a progressive onset and cerebellar atrophy on imaging. We report the case of a 30-year-old woman, with a past history of dry eyes and mouth, who presented a severe cerebellar ataxia worsening over 4 years associated with tremor of the limbs and the head Sjögren's syndrome may raise the risk of heart attack, stroke and pulmonary hypertension, according to research. Sjögren's syndrome is an autoimmune inflammatory disease; the body's immune. Sjögren's (pronounced SHO'-grenz) syndrome is a chronic autoimmune disease in which the body's immune system attacks moisture-producing glands, such as those that produce saliva and tears Cubital tunnel syndrome is a disorder caused by compression (pinching) of the ulnar nerve at the elbow. Repetitive use of the elbow can cause cubital tunnel syndrome. Symptoms include numbness and a pins-and-needles sensation of the ring and little fingers and pain in the elbow. Doctors base the diagnosis on an examination and, if needed, the. Sjögren's Syndrome Definition Sjögren's syndrome (SS) is a disorder in which the mouth and eyes become extremely dry. Sjögren's syndrome is often associated with other autoimmune disorders. It is named for Henrik Sjögren, a Swedish ophthalmologist. Description Like other autoimmune disorders, Sjögren's syndrome occurs when the body's immune system.

Marinesco-Sjögren Syndrome - NORD (National Organization

Nephrotic syndrome (NS) is associated with a hypercatabolic state expressed as an exacerbated degradation of muscle mass. However, the clinical significance of this phenomenon has not yet been investigated. The aim of the study was to evaluate the nutritional status of patients with severe NS (defined as nephrotic range proteinuria with hypoalbuminemia ≤2.5 g/dL) and estimated glomerular. The term atrophy means wasting of body tissue or organ or muscles owing to injury, disease or lack of usage. Muscle atrophy is the muscle wastage or decrease in huge mass of muscle due to several reasons. It can be complete wastage of muscles or partial damage caused due to muscle weakness. In simple terms, [

Sjogren's syndrome - Symptoms and causes - Mayo Clini

  1. High for inflammatory myopathies. Muscle pathology types: IMPP & Other. Sensitivity: 1% to 35%. Antibody class: IgG. MSA target antigen features. Not tissue specific. Usually enzyme protein, not tRNA. Exception is anti-PL-12 with tRNA Ala & enzyme targets. Often expressed in regenerating muscle fibers
  2. ase deficiency, see Adenosine dea
  3. Sjögren's syndrome, an autoimmune disorder, targets moisture-producing glands and can cause systemic symptoms, including fatigue and joint pain. Typically, it affects women around the age of menopause and often occurs with other immune disorders, such as rheumatoid arthritis and lupus. The main symptoms of Sjögren's syndrome are dry eyes.
  4. Sjögren's syndrome is an autoimmune disease characterized by an autoimmune exocrinopathy involving mainly salivary and lacrimal glands. The histopathological hallmark is periductal lymphocytic infiltration of the exocrine glands, resulting in loss of their secretory function. Several systemic manifestations may be found in patients with Sjögren's syndrome including neurological disorders

Cachexia is also called wasting syndrome or anorexia cachexia syndrome. Cachexia is more than only loss of appetite. It is a complex problem. It involves changes in the way your body uses proteins, carbohydrates, and fat. You may also burn up calories faster than usual. People with cachexia lose muscle and often fat as well Wasting syndrome is a metabolic disorder that causes the muscles to deteriorate. It is often caused by an already existing health condition or a disease that triggers the body's immune system to. Isaacs' syndrome is a rare neuromuscular disorder that is characterized by progressive muscle stiffness; continuously contracting or twitching muscles (myokymia); and diminished reflexes. Signs and symptoms generally develop between ages 15 and 60, with most people experiencing symptoms before age 40 The disease attacks the nerve cells responsible for the control of voluntary muscles. Early symptoms include cramping, twitching, or stiffness of the muscles; slurred nasal speech; difficulty swallowing or chewing, and muscle weakness in an arm or leg. Currently, the cause of ALS is not known. ALS is a fatal disease

wide spectrum of clinical manifestations in Sjögren's

  1. Atrophy of the muscles (amyotrophia) of the hand in the practice of a neurologist is encountered in the form of secondary (more often) denervation atrophy (due to a violation of its innervation) and primary (less often) atrophy, in which the function of the motor neuron basically does not suffer (myopathy). In the first case, the pathological process can have different localization, starting.
  2. CUSHING'S syndrome or therapy with any of the glucocorticoids may cause proximal muscular weakness. 1,2 Muscle wasting is usually apparent clinically. Occasional fibers undergoing degeneration and scattered atrophic fibers have been described in muscle biopsy specimens. 1,3,4 In this paper, histochemical studies of affected muscle in two patients with Cushing's syndrome are described and.
  3. Objectives . Sjögren's syndrome (SS) may be complicated by some neurological manifestations, generally sensory polyneuropathy. Furthermore, involvement of cranial nerves was described as rare complications of SS. Methods . We reported 2 cases: the first one was a 40-year-old woman who developed neuritis of the left optic nerve as presenting symptom few years before the diagnosis of SS; the.
  4. cle atrophy. Without early recognition and aggressive treatment, myofiber loss and muscle fibrosis may result in irreversible jaw dysfunc-tion and severe muscle atrophy. Although masticatory muscle myositis was once believed to be a form of polymyositis, fur-ther investigation has demonstrated that the disease represents a very unique myopathy.
  5. Novel protein could reverse severe muscle wasting in disease, aging and trauma Factor found that triggers muscle stem cells to regenerate: complete muscle replacement and movement achieved in.
  6. Muscle atrophy is a condition in which the tissues in the muscles start to weaken and waste away. This can occur as a result of lack of muscle use, malnutrition, disease, or injury. In many cases of muscle atrophy, you can build the muscle..
  7. For some people, joint pain may be the first sign of Sjogren's, even before dry eye and dry mouth. Tenderness and swelling of joints, particularly in the fingers, wrists, and ankles, is a common.

Muscle-Wasting in Old Horses. As horses age, their bodies transform, often in ways owners don't expect. Muscular mass, for example, changes noticeably enough in some horses that certain regions of their bodies take on completely different shapes. Muscle-wasting, also known as sarcopenia, is common in aged horses and describes generalized. Joint pain, Muscle wasting, Numbness or tingling and Pain or discomfort. WebMD Symptom Checker helps you find the most common medical conditions indicated by the symptoms joint pain, muscle wasting, numbness or tingling and pain or discomfort including Peripheral neuropathy, Cauda equina syndrome, and Multiple sclerosis Sjögren's (SHOW-grins) syndrome is an autoimmune disease-that is, a disease in which the immune system turns against the body's own cells. In Sjögren's syndrome, the immune system targets moisture-producing glands and causes dryness in the mouth and eyes

Primary Sjögren's syndrome associated with inclusion body

Particularly intriguing is the relationship between sulfur deficiency and muscle wasting, a signature of end-stage cancer, AIDS, Crohn's disease, and chronic fatigue syndrome. The African rift zone, where humans are believed to have first made their appearance several million years ago, would have been rich with sulfur supplied by active volcanism Some patients with Sjögren's syndrome may have joint paint as a result of fibromyalgia. In general, the pain of fibromyalgia arises from the muscles, although it may be perceived as coming from the joints. Fibromyalgia and joint pain related to Sjogren's syndrome may be hard to differentiate The most frequent causes of adult-onset recurrent infections are human immunodeficiency virus infection, malignancy, and autoimmune diseases, while acquired non-surgical hyposplenism is rare. Although acquired asplenia/hyposplenism have been described in association with celiac disease and, less frequently, with autoimmune diseases such as Sjögren's syndrome, the manifestations in this.

Muscle Wasting and Hashimoto's - Dr

Excess zinc uptake in muscle leads to muscle wasting in cancer, the researchers found, by breaking down mature muscle cells and preventing stem cells from making new muscle fibers. The reason why ZIP14 pumps more zinc into muscles in cachexia was traced back to the systemic effects of cancer Wasting syndrome, also called cachexia, is a condition where a person loses a large portion of weight and muscle mass very quickly as a result of a late state chronic illness. The most common conditions associated with cachexia are cancer, HIV, type 1 diabetes, and multiple sclerosis. When a person has wasting syndrome, they begin to lose. Spinal muscular atrophy 1 (SMA1), also known as Werdnig Hoffmann disease, is a genetic neuromuscular disorder that affects the nerve cells that control voluntary muscles (motor neurons). Without treatment, symptoms of SMA1 become apparent before 6 months of age and include worsening muscle weakness and poor muscle tone (hypotonia) due to loss of the lower motor neurons in the spinal cord and. Many medical conditions predispose you to developing muscle atrophy, according to a 2016 paper from the University of Iowa. Malnourishment, organ failure and AIDS often lead to atrophy. Injuries like burns also lead to a wasting syndrome known as cachexia. Working at height or in outer space can trigger muscle atrophy as well

[Inclusion body myositis associated with chronic

Discovery of naturally occurring protein that could reverse severe muscle wasting in disease, aging and trauma. Share this page on Facebook Share this page on Twitter Share this page on Linkedin Share this page on Baidu Email this page Print this page +Share. 11 February 202 Primary Sjögren's syndrome (pSS) is an autoimmune disease that typically has exocrine gland involvement and can lead to sicca syndrome, although internal organs may also be affected. Due to the ever-growing access to rheumatological diagnostic assessments, including immunological (presence of autoantibodies) and histopathological (salivary.

Sjögren's syndrome is one of the most prevalent autoimmune diseases in the United States, affecting an estimated 7,000,000 people, with only 4,000,000 of those being diagnosed. While it primarily affects the salivary glands and tear ducts, it can also affect other cells and tissues in the body. The present study deals with the sisters of Marinesco-sjögren syndrome without parental consanguinity. Cranial MRI of sisters in a 0.5T superconducting magnet revealed the cerebellar hypoplasia or atrophy, especially in vermis and tonsils with dilatation of IVth ventricle Thenar Atrophy Definition. The thenar region of the palm is the group of muscles in the thick pad just underneath the thumb. Thenar atrophy is an erosion of muscle tissue, which can impair control over the thumb and leave the hand disfigured. The problem can be several different conditions and disorders, including carpal tunnel syndrome. Muscle Wasting Chronic Kidney Disease. The Kidney Disease Solution is an all-in-one three-phase program designed to help individuals reverse kidney damage and enhance their kidney function while soothing the pain from the symptoms. It's made to safeguard you from adding damage to your kidneys so you can avoid transplant and dialysis Piriformis syndrome is a painful condition that develops due to irritation or compression of the sciatic nerve near the piriformis muscle. The piriformis muscle connects the lowermost vertebrae with the upper part of the leg after traveling the sciatic notch, the opening in the pelvic bone that allows the sciatic nerve to travel into the leg